A drug that inhibits the reduction of dihydrofolate to tetrahydrofolate (a later step than that inhibited by sulphonamides). Selective for some bacterial DHF reductases and often used in conjunction with sulphonamides.
Found op http://www.encyclo.co.uk/visitor-contributions.php
<drug> A drug that inhibits the reduction of dihydrofolate to tetrahydrofolate (a later step than that inhibited by sulphonamides). ... Selective for some bacterial dihydrofolate reductases and often used in conjunction with sulphonamides. ... (19 Jan 1998) ...
Found op http://www.mondofacto.com/facts/dictionary?trimethoprim
(tri-meth´o-prim) an oral antibacterial closely related to pyrimethamine; it is almost always administered in combination with a sulfonamide because the two potentiate each other. Used primarily for treatment of urinary tract infections and pneumocystis pneumonia. The sulfate salt is applied topica...
Found op http://www.encyclo.co.uk/local/21001
(from the article `drug`) ...growth by interfering with the synthesis of folic acid. Humans are usually not adversely affected by the drugs, because they do not synthesize ...
Found op http://www.britannica.com/eb/a-z/t/80
It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Trimethoprim was formerly marketed by GlaxoSmithKline under trade names including Proloprim, Monotrim and Triprim; but these trade names have been licensed to various generic pharmaceutical manufacturers...
Found op http://en.wikipedia.org/wiki/Trimethoprim
Type: Term Pronunciation: trī-meth′ō-prim Definitions: 1. An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole.
Found op http://www.medilexicon.com/medicaldictionary.php?t=94011
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