First-pass effect

This is the chemical alteration resulting from biotransformation of a xenobiotic before it reaches the systemic circulation. Such biotransformation by the liver is referred to as a hepatic first-pass effect.

First-pass effect

Biotransformation of a xenobiotic before it reaches the systemic circulation. The biotransformation of an intestinally absorbed xenobiotic by the liver is referred to as a hepatic first-pass effect.

first-pass effect

Type: Term Synonyms: first-pass metabolism
Found on http://www.medilexicon.com/medicaldictionary.php?t=28017

first-pass effect

(from the article `poison`) ...in the gastrointestinal tract must pass through the liver, where they can be biotransformed and thus eliminated before being distributed to other ...
Found on http://www.britannica.com/eb/a-z/f/29
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