Look up: GABA receptor

1. 
   GABA receptor
   Member of a family of receptors for neurotransmitters that includes those for glycine and the nicotinic acetylcholine receptor. Opened by g -amino butyric acid (GABA). There are two main classes; GABA A and GABAC receptors are ionotropic, GABAB receptor is metabotropic. 1. GABAA receptor (ca 250 kD) is a ligand-gated chloride channel specifically blocked by bicuculline and picrotoxin, a hetero-oligomer with (probably) five subunits, generally two pairs of a and b subunits and a g subunit, but there are multiple isoform and splicing variants of these and some additional tissue-specific isoforms. The a chains (53 kD) are needed for binding of benzodiazepine, though the site is probably shared with the g subunit, and the bchains (58 kD) bind GABA. The subunits are thought to form a tight group with the chloride channel in the centre. There is considerable protein sequence similarity between GABAA receptor and the nicotinic acetylcholine receptor. Properties of the receptor can be modified by phosphorylation. Insect GABA receptor resemble vertebrate GABAA but do not bind bicuculline and have significantly different pharmacological profiles. 2. The GABAB receptor (80 kD) is a G-protein-coupled receptor found in the brain and differs from the GABAA receptor both in agonist specificity (baclofenis a specific agonist) and its effects on cells. It is negatively coupled to adenylate cyclase through a G o-protein and thus acts indirectly on N-type calcium channels. Inhibitory effects mediated through this receptor are due to a reduction in catecholamine release. Has sequence similarity with metabotropic glutamate receptors. 3. The GABAC receptor resembles GABAA but is restricted to the retina.
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2. 
   GABA receptor
   Synonym for gamma aminobutyric acid receptor ... <physiology> Ligand gated chloride ion channel forming receptor opened by gamma aminobutyric acid. Two distinct types: A and B. ... A receptor: One of a family of neurotransmitter receptors with fast intrinsic ion channels that includes the glycine receptor and the nicotinic acetylcholine recepto ...
   Found on http://www.mondofacto.com/facts/dictiona
   
   
3. 
   GABA receptor
   The `GABA receptors` are a class of receptors that respond to the neurotransmitter γ-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are three classes of GABA receptors: GABAA, GABAB, and GABAÃ?¡. GABAA and GABAÃ?¡ receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known as metabotropic receptors...
   Found on http://en.wikipedia.org/wiki/GABA_recept
   
   
4. 
   GABAA receptor
   The `GABAA receptor` is one of two ligand-gated ion channels responsible for mediating the effects of Gamma-Amino Butyric Acid (GABA), the major inhibitory neurotransmitter in the brain. The GABAA receptor complex is also the molecular target of the benzodiazepine class of tranquilizer drugs, and hence it is also often referred to as the `benzodiazepine receptor` (although the benzodiazepines do not bind to the same receptor `site` as the endogen...
   Found on http://en.wikipedia.org/wiki/GABAA_recep
   
   
5. 
   GABAB receptor
   `GABAB receptors` (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels.
   Found on http://en.wikipedia.org/wiki/GABAB_recep
   
   
6. 
   GABAC receptor
   The `GABAC receptor` is one of two ligand-gated ion channels responsible for mediating the effects of Gamma-Amino Butyric Acid (GABA), the major inhibitory neurotransmitter in the brain. The GABAC receptor, like the closely-related GABAA receptor, is expressed in many areas of the brain, but in contrast to GABAA, the GABAC receptor has especially high expression in the retina. In addition to containing a GABA binding site, the GABAC receptor com...
   Found on http://en.wikipedia.org/wiki/GABAC_recep